Hannah H. Freeman
In her practice, Hannah advises clients on transactions that are of critical strategic importance, with particular focus in the life sciences industry. Hannah advises a wide range of both public and private companies and investors in a variety of transactions involving corporate and intellectual property matters, including technology licensing and transfer, product development collaborations, joint ventures, mergers and acquisitions, supply and distribution arrangements, co-promotion arrangements, and other strategic commercial agreements. Although much of her practice focuses on the life sciences sector, Hannah also works with companies in many other industries including technology, software, branded and consumer products, sports, media, and finance. Her clients include global bio-pharmaceutical companies such as Pfizer, Shire, Takeda Pharmaceuticals and Boehringer Ingelheim, smaller biotechnology pioneers such as Akebia Therapeutics, Blueprint Medicines, Homology Medicines, Juno Therapeutics, Kiniksa, academic institutions such as The Broad Institute, sports industry players, including the National Football League and the Boston Red Sox, and private equity funds such as TPG, TSG Consumer Partners and Berkshire Partners.
Strategic Life Sciences Transactions
- Advised The Independent Transactions Committee of the Board of Directors of Akcea Therapeutics in connection with the negotiation of an exclusive, worldwide licensing deal with affiliate Ionis Pharmaceuticals related to the commercialization of two of Ionis’ drugs for the treatment of hereditary transthyretin amyloidosis, a progressive and fatal disease resulting from abnormal protein deposits in the peripheral nervous system. This transaction is potentially worth up to $1.7 billion plus profit sharing payments.
- Advised Shire Plc in a collaboration with Rani Therapeutics to exclusively conduct research on the use of Rani’s Pill(TM) technology for the oral delivery of factor VIII (FVIII) therapy for patients with hemophilia A. As part of the collaboration agreement, Shire was allowed an exclusive licensing option to develop and commercialize the Pill(TM) technology following the completion of feasibility studies.
- Advised Takeda Pharmaceutical Company Limited in a $230 million research, development and commercial collaboration and multi-program option and license agreement with Wave Life Sciences Ltd. focused on central nervous system (CNS) disorders, including Huntington’s and Alzheimer’s diseases, amyotrophic lateral sclerosis (known as Lou Gehrig’s disease), and dementia. Depending on the success of licensed programs, Wave may be eligible to receive over $2 billion in cash milestone payments.
- Represented Akebia Therapeutics, Inc. in its exclusive license agreement with Vifor Pharma Group, pursuant to which Vifor is granted the exclusive right to distribute Akebia’s Phase 3 oral anemia drug vadadustat through its network of U.S. dialysis centers. Vifor is also making a $50 million investment in Akebia at $14 a share.
- Represented Akebia Therapeutics, Inc. in the $865 million global expansion of its collaboration and license agreement with Otsuka Pharmaceutical Co. to develop and commercialize vadadustat, an oral hypoxia-inducible factor (HIF) stabilizer currently in Phase 3 development, in Europe, China and other territories.
- Represented Akebia Therapeutics, Inc. in an exclusive licensing agreement with Janssen Pharmaceutical under which Akebia in-licensed a portfolio of well-characterized HIF pathway compounds with potential applications across multiple therapeutics areas.
- Represented Akebia Therapeutics, Inc. in its $1 billion collaboration and license agreement with Otsuka Pharmaceutical Co. for the worldwide development and U.S. co-commercialization of vadadustat, an oral hypoxia-inducible factor (HIF) stabilizer currently in phase 3 development for the treatment of anemia associated with chronic kidney disease.
- Represented Boehringer Ingelheim in connection with the negotiation of a global collaboration to develop and commercialize an anti-IL-23 monoclonal biologic antibody in Phase 3 development for psoriasis and also in development for Crohn's disease, psoriatic arthritis and asthma, as well as an anti-CD-40 antibody in Phase 1 development, under which AbbVie agreed to pay BI $595 million upfront as well as additional development and regulatory milestone payments and royalties on net sales.
- Represented Homology Medicines in its research and development collaboration with Novartis to use Homology’s gene editing technology to develop new treatments for select ophthalmic targets and hemoglobin blood disease.
- Represented Ironwood in its agreement with Allergan for the U.S. co-promotion of eluxadoline.
- Represented Lantheus Holdings, Inc., parent company of Lantheus Medical Imaging, in its $65 million definitive license agreement with GE Healthcare for the continued Phase III development and worldwide commercialization of flurpiridaz F 18.
- Represented Pfizer in its collaboration with Merck KGaA focused on the development and marketing of anti-PD-L1 antibodies, the largest deal in the pharmaceuticals industry for a single asset in Phase 2 clinical development. Merck received $850 million upfront for the opportunity to develop the drug with Pfizer, and could receive an additional $2 billion in milestone payments. This transaction won the LES 2015 “Deal of Distinction Award” for the life sciences sector.
- Represented Pfizer in a strategic agreement with MedGenesis Therapeutix, granting Pfizer an exclusive worldwide option to license MedGenesis’s glial cell line-derived neurotrophic factor protein and convection enhanced delivery technology to be used in research for potential treatments for Parkinson's disease.
- Represented Prevail Therapeutics, Inc., a startup focused on new biologics and gene therapies for Parkinson’s disease, in its formation, Series Seed financing, initial IP in-licensing, and with respect to various general corporate matters as ongoing outside counsel to the company. Prevail was launched and initially financed by The Silverstein Foundation and OrbiMed. In conjunction with its launch, Prevail entered into an exclusive worldwide license agreement with REGENXBIO Inc. to develop and commercialize gene therapy products using REGENXBIO’s NAV AAV9 vector for the treatment of Parkinson’s and other related neurodegenerative diseases.
- Represented Proteostasis Therapeutics in a $1.2 billion worldwide collaboration deal with Astellas Pharmaceuticals to research and develop therapeutic candidates that modulate the Unfolded Protein Response.
- Represented Sarepta Therapeutics in connection with exclusive license and collaboration agreement with Summit Therapeutics pipeline for Duchenne muscular dystrophy.
- Represented Shire in connection with the negotiation of an amended and restated collaboration and license agreement with Sangamo.
- Represented Takeda Pharmaceuticals in connection with the spin-out of Cerevance, a neuroscience company focused on discovering and developing novel therapeutics for neurological and psychiatric disorders.
- Represented Takeda Pharmaceuticals in its collaboration with Roivant Sciences to launch Myovant Sciences Ltd., a biopharmaceutical company focused on women's health and prostate cancer. Takeda granted Roivant exclusive licenses to relugolix, a phase 3 candidate that is being developed as a gonadotropin-releasing hormone receptor agonist for entering fibroids, endometriosis and prostate cancer, and RVT-602, a novel oligopeptide kisspeptin receptor agonist being developed for the treatment of infertility in females.
- Represented the National Football League in its spin-out and repositioning of NFL On Location, its premium events and hospitality business.
- Represented a global children’s clothing company in implementing domestic and international licensing, distribution, supply and joint venture relationships.
- Represented Altamont Capital Partners in a transaction in which it will provide capital to support Douglas Products, LLC’s purchase of the Vikane and ProFume businesses from Dow AgroSciences,
- Represented Berkshire Partners in its $2 billion transaction to acquire and combine Lightower Fiber Networks and Sidera Networks.
- Represented Pfizer in its $130 million acquisition of two meningitis vaccines from GlaxoSmithKline.
- Advised TSG Consumer Partners, Kohlberg & Co LLC, Berkshire Partners, TPG Capital, L.P., Gridiron Capital, Bain Capital LLC and other private equity firms with respect to intellectual property matters in connection with their investments in the consumer product, technology, life sciences and industrial sectors.
- Represented an advertising agency on corporate and commercial matters, including legal review and clearance of advertising material.
- Represented various authors in connection with publication and other publicity agreements.
- Co-chair, The Boston Bar Association Life Sciences Conference (October 3, 2017)